Explosions were also reported in Syria and Iraq, the media outlets added.
A blast in Iran's Isfahan was heard near the airport and the 8th Army Air Force Base, Iran's Fars news agency said.
Iranian air defense forces have been repelling an air strike in the skies over the city of Isfahan, Mehr News Agency wrote, publishing a video of the incident. The Iranian authorities canceled flights over Tehran, Isfahan, and Shiraz temporarily.
Air defense systems in several provinces of Iran on Friday were firing shots in response to the approach of small unmanned aerial vehicles (UAVs), Iranian state news agency IRIB reported, citing sources.
The report said a loud explosion heard in several provinces of Iran was caused by the activation of air defense systems to intercept several small unidentified UAVs.
Iranian air defenses reportedly shot down several drones over the Isfahan province in central Iran. Earlier on Friday, Iranian news agency IRNA reported that Iran's air defense systems were activated in several provinces of the country.
IRNA also reported that air defenses in northwestern Iran were triggered by the approach of an unidentified flying object. Following reports of explosions heard west of the city of Tebriz and near Vadi-e Rahmat, IRNA reported that Tebriz's air defenses fired at the unknown object.
There were no explosions in the city and the situation in Tebriz is calm, the report said.
Israeli Defense Forces declined to comment the situation around Iran, CNN reports.
Tensions in the Middle East escalated after Israel launched an attack on the consular section of the Iranian embassy in Damascus, Syria, in early April. The attack leveled the diplomatic building and killed seven officers of Iran's elite Revolutionary Guards, including two generals.
On April 13, Tehran launched its first direct attack on Israeli territory in retaliation for the embassy attack. The counterattack demonstrated Tehran's ability to penetrate Israeli air defenses.