The attack was the latest in a series of similar recent jihadist offensives which a week ago led the government to extend a state of emergency across most of the West African nation for another six months.
The village of Kie was attacked by "unidentified armed individuals on Friday evening", a local official said on the condition of anonymity, reporting that at least a dozen people were killed.
Local residents also confirmed the attack. The attackers came in "large numbers (and) surrounded the village", said one resident, who added that some homes were set on fire.
The latest attack adds to a bloody week for the impoverished landlocked Sahel state, which is struggling with a jihadist insurgency that swept in from neighbouring Mali in 2015.
Around 20 people were killed in a series of raids Thursday on villages in the country's troubled north, sources said. Moreover, there were reports Friday that another 20 people had been killed in separate attacks in eastern Burkina Faso.
Armed men on Monday raided the village of Kaongo in the southeastern province of Koulpelogo, killing at least 11 people including two women and children.
Two days later the neighbouring village of Bilguimdoure was targeted, "leaving around 10 dead", a local official said. The attackers torched homes and stores in the two villages and made off with cattle, the official added.
People living in the district said that local residents were fleeing the area, terrified of further attacks.
Since 2015, Burkina Faso has been facing mounting violence from jihadist organisations, including the Group to Support Islam and Muslims (GSIM) and Islamic State in the Greater Sahara (EIGS).
More than 10,000 civilians, troops and police have died in the insurgency, according to NGO estimates, while at least two million people have fled their homes and more than a third of the country lies outside the government's control.
On Friday, Australian Foreign Minister Penny Wong said that Australian doctor Kenneth Elliott, 88, had been freed more than seven years after he and his wife were snatched in Burkina by Al-Qaeda*-linked jihadists.
The six-month extension of the state of emergency – adopted unanimously on May 12 by the interim parliament – will now remain in effect through to October 29.
It has been imposed in eight of the country's 13 regions since the end of March.
It allows security forces to conduct searches of homes, day or night, and restricts some fundamental freedoms such as the freedom of movement and assembly.
*terrorist organization banned in Russia and many other countries