The health department in the South African province of Gauteng on Sunday reported 19 new cases of Cholera in Hammanskraal region, including 10 deaths.
The victims included a three-year-old child and nine adults, the department added in a statement.
According to the health authorities, at least 95 people since last Monday in the region have visited hospitals showing symptoms of cholera and at present 37 people have been admitted in critical condition.
In addition, the local municipality has issued a notice urging communities of Hammanskraal not to drink tap water and has supplied water tankers to the hospital and surrounding communities.
South Africa reported its first cholera death in February, after the virus arrived in the country from Malawi where cholera outbreaks happen regularly, usually in the rainy season from November to March.
The previous outbreak in South Africa occurred in 2008-2009, when about 12,000 cases were reported after an outbreak in neighboring Zimbabwe, resulting in a surge of imported cases and subsequent local transmission.